West Ham are without a recognised left-back after Arthur Masuaku joined Aaron Cresswell on the sidelines with a knee injury.
Central defender Winston Reid will return, but Andre Ayew, Andy Carroll and Diafra Sakho remain out.
Southampton boss Claude Puel is expected to hand a start to Charlie Austin, who has scored four goals in his last three matches.
Fellow striker Jay Rodriguez is out with a groin problem.
MOTD COMMENTATOR’S NOTES
Guy Mowbray: “The form guide says Southampton to win, with three victories in a row suggesting they’re on the right track after an initially sluggish start under Claude Puel.
“Charlie Austin has scored in all those wins, and he’ll relish the chance to net again against the club that publicly questioned his fitness last year after deciding against signing him.
“West Ham’s problem lies at the other end of the field, and ;the problem is big’ says Slaven Bilic.
“We might then reasonably expect a cautious approach from his side, with defensive discipline paramount.
“Talking of which, here’s a quirky fact: referee Jonathan Moss has sent someone off in each of the last six Hammers games he has officiated!”
WHAT THE MANAGERS SAY
West Ham manager Slaven Bilic: “Injury-wise we look much better than at the beginning of the season. We have a good team and I expect us to be really good in every way on Sunday afternoon.
“I want the fans to be behind us, and they will be.
“We need them all the time, but especially now to help get out of this situation. I have no doubt they will be very positive.”
Southampton manager Claude Puel: “We can see the good work on the training sessions and in every game, we are strong in defence and also with good possibilities on the counter-attack, playing good football, even with different players out on the pitch.
“All of the squad can take confidence from this, to show that it is possible to play these many games every three days, which is what we challenged the squad to do at the start (of the season).
Southampton have the lowest shot conversion rate in the Premier League, just 6.45%. Shane Long is probably most to blame for that, but Charlie Austin is a finisher and, as he showed last weekend against Swansea, if he is picked and gets a chance, he will take it.
West Ham have been struggling at the back but they have been working hard to improve defensively, and it will come.
- Think you can do better than Lawro? Predict the score for this match and the rest of this round’s Premier League fixtures in our Predictor game.
- West Ham have only failed to score in one of their 14 home Premier League meetings with Southampton: a 1-0 defeat in December 2002.
- The team scoring first has gone on to lose this fixture at West Ham in each of the last three seasons, with the Hammers coming from behind twice.
West Ham United
- West Ham have conceded four goals in consecutive Premier League games for the first time since March 2008, when they conceded four goals in three straight games (0-4 v Chelsea, Liverpool and Tottenham).
- The Hammers have conceded at least two goals in 12 of their last 15 league matches, letting in 33 goals overall.
- They have lost five of their last six league matches.
- West Ham have scored in each of their last 13 home league games, netting at least twice on nine occasions.
- Michail Antonio has scored 10 headed Premier League goals in 2016 – twice as many as any other player.
- Southampton kept their first Premier League clean sheet in 17 matches, dating back to February, against Swansea last weekend.
- The Saints have scored just four goals in their five league games this season and are yet to score more than once in a match.
- They have conceded three penalties so far this season.
- Charlie Austin has scored four times in his last three games in all competitions after a run of nine games without a goal.
- Claude Puel is only the seventh French manager to win a Premier League game. The others are Alain Perrin, Arsene Wenger, Gerard Houllier, Jacques Santini, Jean Tigana and Remi Garde.
SAM (Sports Analytics Machine) is a super-computer created by @ProfIanMcHale at the University of Salford that is used to predict the outcome of football matches.