West Ham goalkeeper Adrian is the only injury absentee for the club’s final game at Upton Park after 112 years.
The Spaniard is out with a calf injury so Darren Randolph will deputise.
Manchester United forward Anthony Martial is a doubt after withdrawing from Saturday’s win at Norwich because of a tight hamstring.
Matteo Darmian is sidelined by an ankle injury and Marouane Fellaini is banned, but Daley Blind and Marcus Rashford could be recalled.
WHAT THE MANAGERS SAY
West Ham manager Slaven Bilic: “It’s a big game for a couple of reasons and one of them is that this is the last game ever at Upton Park. Then, if you add to that it’s a very important game for us and for Manchester United, as both teams need to win the game, it makes it mega-big!
“It’s a special one and a once-in-a-lifetime kind of game. It’s going to be emotional but we have to channel those emotions to be our motivator in order to win.
“One part of me is happy we are moving forward with more capacity and everything, but another part of me will miss this special kind of stadium. It’s like a home.
“No matter where you move, even if it is to a fancier house or apartment, still your favourite home is your first.”
Manchester United manager Louis van Gaal: “We have to win our matches because otherwise we cannot be in the first four – that’s the pressure that we have. We have to fight until the end.
“West Ham are a very good team – it’s not for nothing they’re in the top six of the table. We were lucky in the FA Cup. I think we deserved to win but we were lucky West Ham had a goal disallowed in the last minute.”
Manchester United are unbeaten in the last 14 Premier League meetings (W11, D3).
The Hammers have failed to score in eight of the last 13 league encounters.
West Ham United
This will be West Ham’s 384th and final Premier League game at Upton Park. A win will take them to 601 points at home in the competition (W167, D97, L119).
Saturday’s 4-1 defeat by Swansea was their worst home loss of the season – and first at Upton Park since August.
That result also ended West Ham’s 10-match unbeaten run, as well as their Champions League hopes.
The Hammers have only averaged 0.93 points from Premier League games played on a Tuesday (P29, W6, D9, L14). Manchester United have averaged an unrivalled 2.19 points from Tuesday fixtures (P43, W28, D10, L5),
Louis van Gaal’s side have lost only once in their last seven Premier League games (W5, D1).
They need two points to surpass their lowest ever Premier League tally of 64 points.
United have kept a league-high 18 clean sheets this season.
Wayne Rooney has scored 11 times in 15 Premier League appearances against West Ham, including a record seven goals at Upton Park by a visiting player.