Liverpool’s long-standing rivalry with Manchester United is renewed on Monday, as Jurgen Klopp’s side face Jose Mourinho’s men at Anfield.
Elsewhere, Everton travel to Manchester City, looking to pick up where Tottenham left off before the international break. Spurs inflicted Pep Guardiola’s first defeat as City boss on Oct. 2, and the Catalan will be looking for a response.
At the other end of the table, it’s an early relegation scrap, as the league’s two winless sides, Stoke and Sunderland, do battle.
Who will come out on top? Predict the winners in each Premier League match by voting in our polls.
LIVERPOOL: The visit of Manchester United is the fixture Liverpool supporters look forward to more than any other, and with the Kop’s public enemy No.1 Mourinho now in charge of United, the game has added spice. Throw in the fact it’s a night game under the lights and Anfield is sure to be a cauldron of emotion on Monday. On such occasions the Reds usually come out on top.
Prediction: Liverpool 3-2 Manchester United — David Usher
MAN UNITED: Mourinho got it wrong for his first big game in charge of United, the 2-1 defeat to Manchester City, so hopefully he has been working out a way to get a better result against Liverpool. He has a good record against them and United have won their last four league games against them too. That said, Liverpool have started the season well and have a new found confidence with Klopp. Being at home further tips the balance in their favour. Prediction: Manchester United 2-2 Liverpool — Scott Patterson
MAN CITY: Clear of the international break at last, City need to restart their winning ways after hiccups at Celtic and Tottenham. Everton, with results slipping after a good start, are looking for a first league win over City since March 2013. Can Ronald Koeman achieve what David Moyes regularly did and throw a spanner in the works?
Prediction: Manchester City 2-1 Everton — Simon Curtis
EVERTON: Guardiola’s Manchester City are Everton’s biggest test thus far and should indicate the current level of this new-look squad. Romelu Lukaku’s fitness is key, as his absence would make a difficult fixture that much tougher while the Blues aim to bounce back from a three-game winless run before the international break.
Prediction: Manchester City 2-1 Everton — Luke O’Farrell
CHELSEA: A return to winning ways at Hull that featured just the second clean sheet of the season was most welcome, even if it still saw a slow start for the third straight match. A repeat against champions Leicester could be disastrous because, although their league form might be erratic, in Jamie Vardy and Riyad Mahrez they possess players capable of exploiting any lethargy, while new signing Islam Slimani has shown he knows his route to goal.
Prediction: Chelsea 2-1 Leicester — Phil Lythell
LEICESTER: An away trip to Chelsea is the last thing Leicester need. The match sees Claudio Ranieri return to his former club and last time, he received a guard of honour as City celebrated an unlikely Premier League title on the final game of 2015-16. Five months later and the visit to Stamford Bridge is likely to be a more humbling experience. City can’t stop shipping goals on the road and that isn’t likely to change in Saturday’s early kickoff. Prediction: Chelsea 2-0 Leicester — Ben Jacobs
ARSENAL: With seven wins in eight games, Arsenal should have enough forward momentum to resist any new manager bounce from the appointment of Bob Bradley. The defence looks sound and the attack has clicked: this should be fairly comfortable.
Prediction: Arsenal 2-0 Swansea — Tom Adams
SWANSEA: The Swans have a good record against Arsenal, and the away side have a good record in this fixture, with the visitors winning the last three. Swansea are the away side on Saturday, and given the team will be likely trying to impress new manager Bradley, Swansea’s hex over Arsenal might yet continue.
Prediction: Arsenal 1-2 Swansea — Max Hicks
STOKE: It’s a basement blockbuster at the bet365 Stadium, where Stoke will be eager to build on their run of (slightly) improved form against the only side in the league worse off than they are. Fans will be hoping that Joe Allen recovers from the injury he picked up on international duty to inspire the Potters to their first three points of the season.
Prediction: Stoke 2-0 Sunderland — James Whittaker
SUNDERLAND: Another painful disappointment or a game that finally kick-starts the season? Squad deficiencies have worsened with injuries and Sunderland must be wary of the bounce Stoke may get from an unexpected point at Manchester United. But there is always hope that Jermain Defoe, just turned 34, can be a hero in manager Moyes’ time of need.
Prediction: Stoke 0-1 Sunderland — Colin Randall
WEST BROM: The Baggies return from the international break facing a tough run of fixtures, beginning with a home game against Tottenham. Tony Pulis will need Darren Fletcher and Claudio Yacob on top form to deal with a powerful, technically gifted Spurs midfield.
Prediction: West Brom 0-2 Tottenham — Matthew Evans
TOTTENHAM: Following impressive wins against CSKA Moscow and Manchester City, Spurs will approach this game with optimism. The one fly in the ointment is the possible disruption caused by the international break: Mauricio Pochettino will have three days at most to reunite his squad. But Spurs should be full of confidence.
Prediction: West Brom 0-2 Tottenham — John Crace
CRYSTAL PALACE: The Eagles face a West Ham side struggling for comfort at home, laying the foundations for frustration in away games too. Palace have a great opportunity to continue their unbeaten run and with Christian Benteke scoring goals for fun at the moment, they have the perfect attacker to help them with that goal.
Prediction: Crystal Palace 3-1 West Ham — Rob Sutherland
WEST HAM: Quite which West Ham team is likely to emerge after the international break is anybody’s guess. The Hammers need to start winning soon and overcoming local rivals would be a good start. Palace are in good form however and it will be difficult.
Prediction: Crystal Palace 2-2 West Ham — Peter Thorne
BOURNEMOUTH: The Cherries will be expecting all three points this weekend as they host a struggling Hull side who have conceded 12 goals in their last four games. Bournemouth also found some form themselves before the international break and it looks like Eddie Howe has finally discovered his best XI. A routine win.
Prediction: Bournemouth 2-0 Hull — Will Kent
HULL CITY: After a horror run of games brought consecutive defeats against Arsenal, Liverpool and Chelsea, the emphasis will be on Hull City avoiding a fourth league loss in succession at Bournemouth. The away games at Swansea and Burnley this season ought to provide optimism after returning four points and so long as confidence is still intact, the Tigers can return from the south coast with a draw. Few would grumble at that outcome. Prediction: Bournemouth 1-1 Hull — Phil Buckingham
SOUTHAMPTON: Saints can move a step closer to breaking a 94-year-old club record for successive clean sheets by recording a seventh successive shutout against a Burnley side yet to score away from home. In-form striker Charlie Austin will be confident of netting against his former club.
Prediction: Southampton 2-0 Burnley — Alex Crook
BURNLEY: The Clarets have yet to score a goal away from home this season and while their new 4-5-1 shape has proven effective at home in the absence of suspended striker Andre Gray, there are concerns lone striker Sam Vokes will be too isolated against a team as comfortable on the ball as Southampton. The Saints have kept six clean sheets in a row and are likely to extend that run on Sunday, while former Claret Austin is bound to score against his old club again. Prediction: Southampton 2-0 Burnley — Jamie Smith
MIDDLESBROUGH: Boro need to pick up the pace and start picking up the points to jump start their lacklustre season. Watford are ideal opponents, as they are not yet Premier League heavyweights and have defensive flaws that a more innovative Boro lineup could exploit. However, Watford have scored more goals than any other side in the bottom half, so it may be a cagey affair from both teams.
Prediction: Middlesbrough 1-1 Watford — Catherine Wilson
WATFORD: Troy Deeney needs one more goal to reach the 100 mark for the Hornets and having scored on six occasions against Middlesbrough in the past, he’ll be hopeful of reaching the landmark on Sunday. The International break provided Walter Mazzarri a chance to work on the defensive shape of his team, who are yet to keep a clean sheet this season. Achieving one here would be a welcome fillip after indifferent recent form. Prediction: Middlesbrough 0-1 Watford — Mike Parkin
Can Liverpool keep up their good form with a win over arch rivals Manchester United at Anfield? Will Manchester City hit back following defeat at Tottenham by beating Everton at home?
Have your say on those matches and the rest of the Premier League action this weekend by voting in our match polls and joining the debate in the comments below.