Watford forward Stefano Okaka faces a month with a hamstring injury picked up on his club debut last weekend.
Younes Kaboul and Sebastian Prodl both face late fitness tests after picking up knocks in the same game.
Manchester United’s Wayne Rooney, Antonio Valencia and Luke Shaw are back in the squad after being rested for the Europa League defeat in midweek.
Eric Bailly will be assessed after getting a knock in that game. Henrikh Mkhitaryan is nursing a thigh problem.
MOTD COMMENTATOR’S NOTES
Steve Bower: “These two teams go into this one on the back of contrasting emotions.
“While Manchester United are digesting a derby defeat and a lacklustre Europa League loss, Watford finally created some positive headlines under Walter Mazzarri by beating West Ham.
“The new head coach is still searching for the right formula, having already used 22 players in the league this season, but the importance of his first win and the manner of it cannot be underestimated.
“He’ll know his opposite number will be demanding a reaction at Vicarage Road.
“Rightly or wrongly, Jose Mourinho left nobody in any doubt of his opinions. If his desire to win the league in his first season is to be achieved, this is a fixture United have to be winning.”
Manchester United manager Jose Mourinho: “It is a new event, it is another match. It starts minute zero at 0-0 so I think it has nothing to do with the previous two matches.
“But obviously when you lose matches, the mood, the feeling, is not the same. That’s normal. But I think we are experienced players and the players are very good guys and I know they want to win and work, so that’s what we have to do.”
Manchester United will want to bounce back straight away from last weekend’s derby defeat, and I don’t think Thursday’s Europa League game against Feyenoord will distract them.