Spurs made light work of the Hammers back in November, winning 4-1 at White Hart Lane, but face a tougher test this time with Slaven Bilic’s side unbeaten at home since August.
Throw in the fact it’s a hotly contested London derby, and the last between these clubs at the Boleyn Ground, and we could be in for one of the games of the season.
Mauricio Pochettino is again without Mousa Dembele, Jan Vertonghen and Clinton N’Jie, while Dele Alli and Tom Carroll are in the squad but doubts.
So who will the Argentine name in his XI to face West Ham? Click the right arrow to see our predicted line up…