Tottenham are hopeful Harry Kane will play despite missing their midweek Europa League win with a broken nose.
Mousa Dembele and Tom Carroll are out with respective groin and Achilles problems, while Jan Vertonghen and Clinto Njie remain absent.
Swansea have a fully-fit squad after a 15-day break since their last game.
Their only pre-match concern has been head coach Francesco Guidolin but the Italian is expected to be in the dug-out following a chest infection.
MOTD COMMENTATOR’S NOTES
Simon Brotherton: “I think it was reassuring for Tottenham’s players and their supporters that they comfortably dispatched Fiorentina in Europe in midweek without the services of Harry Kane.
“He’s been immense this season and has scored 15 goals in his last 17 league games, but winning so comfortably without him against a good side must provide a psychological boost in case he misses another game.
“Swansea have never won a league game at White Hart Lane in 17 previous attempts, but have picked up in recent weeks. Nonetheless, this is a game Tottenham need to win to keep their title challenge fully on course.”