Tottenham midfielder Mousa Dembele is set to make his first Premier League appearance of the season on Sunday after completing a domestic suspension.
Left-back Danny Rose remains out because of a hamstring injury.
Sunderland pair Lee Cattermole and Steven Pienaar are back in training after injuries and could be involved.
Billy Jones and Victor Anichebe are not yet fit enough to return, while Fabio Borini, Sebastian Larsson and Vito Mannone are long-term absentees.
MOTD COMMENTATOR’S NOTES
Jonathan Pearce: “It has been a grizzly week for both clubs. Wembley woe for Spurs ripped their Champions League dreams. Playing there will inspire the opposition, as it did when Arsenal tried the same experiment.
“Sunderland’s home hammering by Everton rang alarm bells. They were unlucky to lose at Manchester City on the opening weekend. Since then they’ve been poor.
“I saw them capitulate 5-1 at the Lane in April 2014. They looked doomed that night but somehow stayed up. They might need another great escape.
Tottenham manager Mauricio Pochettino: “It’s true that after Wednesday I am thinking about rotating the team a bit.
“We’ll see what happens tomorrow when we assess all the players and take the best decision for the team.”
Sunderland manager David Moyes: “I’m certainly up for the challenge – that’s what I came for. When I wanted to come back in, I wanted somewhere that excited me – I’d like to say this was really exciting, but maybe not in the way I hoped!
“But there has to be a realistic element to this. There is a building job and we are up against it, undoubtedly.
“But we have got a great chance to prove ourselves and we have got a great chance to show what we can do.”
Sunderland were poor defensively in their 3-0 home defeat by Everton on Monday night. When the Toffees raised their level in the second half, it was all over.
This looks like another big test for the Black Cats. I would go so far as to say that it looks to be a home banker for Tottenham.