Tottenham midfielder Mousa Dembele is likely to be suspended after being charged with violent conduct following Monday’s draw with Chelsea.
Dele Alli is already banned, while Danny Rose and Toby Alderweireld are both slight injury doubts.
Southampton manager Ronald Koeman could name an unchanged side after their 4-2 win over Manchester City last weekend.
Out-of-favour striker Graziano Pelle was dropped from the last squad but could be involved against Tottenham.
MOTD COMMENTATOR’S NOTES
Steve Wilson: “It won’t be easy after the disappointment of Monday night at Chelsea, but Spurs have plenty of motivation to lift themselves for this game against Mauricio Pochettino’s former club.
“Here, in ascending order of significance, are their reasons to be fairly cheerful:
•A goal would ensure their highest ever Premier League tally.
•A point would guarantee them a highest ever Premier League finish.
•A win would mean that only a freakish reversal in goal difference could deny them second place, and most of all they’d be all but certain of finishing above Arsenal for the first time since 1995.
“Southampton find themselves in a similar position, knowing that three points would equal their best ever Premier League total and go a long way to ensuring Europa League qualification.”
This will be a case of ‘after the Lord Mayor’s Show’ but it will still mean a lot to Tottenham boss Mauricio Pochettino to round off such an excellent season with a good performance against his former club in their final home game.
The circumstances will suit Southampton, though. They made the most of an atrocious display by Manchester City last week and have really found some form.
- Think you can do better than Lawro? Predict the score for this match and the rest of this round’s Premier League fixtures in our Predictor game.
- Tottenham are unbeaten in their last seven league matches with Southampton – winning six and drawing the other.
- Saints haven’t beaten Spurs since March 2005, while their last win at White Hart Lane was in September 2003.
- Tottenham are unbeaten in their last eight league matches, although they have drawn half of those games.
- Spurs haven’t lost at home in the league since 13 January – when defeated by champions Leicester.
- Harry Kane has scored 14 goals in his last 15 Premier League appearances.
- Spurs have won a league-high 19 points from losing positions this season. However, they’ve also dropped 17 points from leading positions – only Liverpool (19) and Everton (18) have fared worse.
- Southampton have only lost one of their last eight league matches (W5, D2).
- They have scored 12 goals in their last four Premier League games.
- Saints need just three points from their remaining games to equal their best ever points total of 60 in a Premier League season, which was set last season under Ronald Koeman.
- Koeman’s side have collected 33 points in 2016; only the current top two in the Premier League have won more (Leicester 38 and Tottenham 35).
- Sadio Mane has scored seven goals in his last six Premier League games for Southampton – this comes after a run of 19 league appearances without scoring.
SAM (Sports Analytics Machine) is a super-computer created by Professor Ian McHale at the University of Salford that is used to predict the outcome of football matches.