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Tottenham midfielders Mousa Dembele and Christian Eriksen are expected to miss the Europa League last-16 tie against Borussia Dortmund at White Hart Lane.
Neither player trained on Wednesday because of minor knocks, with Spurs boss Mauricio Pochettino confirming they were unlikely to play.
Defender Jan Vertonghen and forward Clinton Njie (both knee) have returned to training but are not yet available.
Spurs, who are second in the Premier League, trail 3-0 after the first leg.
A much-changed Spurs side were outclassed by the German giants, who took a commanding lead through Pierre-Emerick Aubameyang and Marco Reus’s brace.
It was the heaviest defeat of the season for Pochettino’s side and leaves them needing to win by a four-goal margin to reach the quarter-finals inside 90 minutes.
Stats of the day
Tottenham are unbeaten in nine European home games, winning seven and drawing two
Spurs have won both of their most recent Europa League home matches by three-goal margins, beating Monaco 4-1 and Fiorentina 3-0
Dortmund have not lost by three goals in Europe since a 3-0 defeat by Real Madrid in the 2013/14 Champions League quarter-finals
Dortmund are bidding to become the fifth club to win all three major Uefa trophies (European Cup/Champions League, Europa League/Uefa Cup and Cup Winners’ Cup) after Ajax, Bayern Munich, Juventus and Chelsea