Spurs are playing catch up in their Champions League group already.
Mauricio Pochettino’s team travel to Moscow to play CSKA with one loss to their name already having been beaten by Monaco at Wembley.
“It’s true that it will be a tough game,” he told tottenhamhotspur.com. “We must win because we need to go to the next round and to have the possibility to go through to the next round we need to take the three points.”
Moussa Sissoko is among five members of the first team left behind by the manager as a result of injury, so talkSPORT looks at how the team may line up without their stricken players.
Scroll through the gallery to see the possible Tottenham XI.