Spurs boss Maurico Pochettino is without suspended star Dele Alli and injured trio Danny Rose, Victor Wanyama and Erik Lamela.
But he has vowed to learn from last season, saying: “I think that is so important, that experience from last season.
“It was a very painful experience. We could not be at the level we should have been but today, it’s not an excuse. We need to be ready to compete at a higher level.”
Tottenham (3-4-3): Lloris; Alderweireld, Sanchez, Vertonghen; Aurier, Dier, Dembele, Davies; Eriksen, Kane, Son.
Dortmund (4-3-3): Burki; Piszczek, Papastathopoulos, Toprak, Zagadou; Sahin, Castro, Gotze; Philipp, Pulisic; Aubameyang.
Referee: Gianluca Rocchi (Italy)
7.45pm BT Sport 3