Arsenal star Granit Xhaka comes up against his brother Taulent, who is also expected to play in a holding midfield role for the visitors.
Fellow midfielder Francis Coquelin has been ruled out for up to three weeks with a knee injury suffered against Chelsea at the weekend.
ARSENAL (4-2-3-1): Ospina; Bellerin, Mustafi, Koscielny, Monreal; Cazorla, Xhaka; Walcott, Ozil, Iwobi; Sanchez.
BASEL (4-2-3-1): Vaclik; Lang, Suchy, Balanta, Traore; Xhaka, Zuffi; Bjarnason, Delgado, Steffen; Doumbia.
REFEREE: Danny Makkelie (Holland).
BT Sport Extra 7.45pm