The Black Cats have just five games remaining to preserve their top-flight status and they are currently one point behind 17th-placed Norwich.
Arsenal will be no pushovers, though, as Arsene Wenger’s side look to secure another top-four finish after their title bid has faltered.
The fourth-placed Gunners are now unbeaten in their last six league outings after a wobble, while Sam Allardyce’s 18th-placed Wearsiders have won just two of their last ten.
The teams are in from the Stadium of Light:
Sunderland: Mannone, Yedlin, Kone, Kaboul, Van Aanholt, Kirchhoff, Borini, Cattermole, M’Vila, Khazri, Defoe.
Subs: Jones, Larsson, Rodwell, N’Doye, Pickford, O’Shea, Watmore.
Arsenal: Cech, Bellerin, Mertesacker, Koscielny, Monreal, Ramsey, Elneny, Sanchez, Ozil, Iwobi, Giroud.
Subs: Gabriel, Wilshere, Ospina, Walcott, Welbeck, Campbell, Coquelin.