Stoke goalkeeper Jack Butland has been ruled out for the rest of the season after fracturing his ankle whilst playing for England.
Jonathan Walters is also absent for the Potters following surgery on a knee cartilage problem.
Swansea forward Andre Ayew will miss a third successive game because of an ankle injury.
Jefferson Montero and Modou Barrow will have their fitness assessed after returning from international duty.
MOTD COMMENTATOR’S NOTES
Alistair Mann: “Four points ahead of their tally at this stage of last season, Stoke are well placed to record their best-ever Premier League campaign.
“Under Mark Hughes they’ve had their first ever top-10 finish, notched up their highest points haul and are now set for another landmark.
“Five points off fourth-placed Manchester City, who they still have to play, Champions League is perhaps stretching their potential too far. Europa League qualification via the league is certainly not.
“Meanwhile, three wins in four has almost certainly secured Swansea’s status among the game’s elite. Their task this weekend is to attempt to secure a first Premier League win at the Britannia Stadium.”
Swansea head coach Francesco Guidolin on speculation he may leave in the summer: “If I can work here in the future, I will be very happy. I am proud and happy to be here, but I do not know what the future holds.
“I can say that the most important thing is Swansea being safe, and afterwards we will see.”
The Swans are not mathematically safe yet, but they are no longer in any serious danger of the drop after winning three of their last four games.