Southampton predicted XI v Sparta Prague: Saints chasing first win under Claude Puel in Europa League
The Saints will be without club-record signing Sofiane Boufal as the French midfielder continues to build up his match fitness. Jeremy Pied is also ruled out due to a long-term injury.
Southampton will be eager to seize their chance on the European stage after being knocked out by FC Midtjylland in the play-off round last season.
Here talkSPORT looks at how Southampton could line up against Sparta Prague – Who will play in midfield? Will Charlie Austin be preferred to Shane Long?
Leave your starting XI below.