Listen on BBC Radio 5 live and BBC local radio; text commentary on the BBC Sport website
Sheffield Wednesday defender Daniel Pudil is likely to be available after recovering from a thigh injury which has caused him to miss three games.
Sam Hutchinson is a doubt with a back injury, while Lucas Joao is likely to miss out with a groin problem.
Brighton midfielder Dale Stephens is suspended but left-back Gaetan Bong is available again after a ban.
Defender Liam Rosenior, midfielder Beram Kayal (both ankle) and winger Kazenga LuaLua (knee) are all out.
Wednesday beat the Seagulls in the Championship play-off semi-finals last year but were then beaten 1-0 by Hull at Wembley in the play-off final.
BBC Radio Sussex’s Johnny Cantor:
“Brighton & Hove Albion will want to banish the memory of their last trip to Hillsborough in last season’s play-off semi-final first leg when four Seagulls players went off injured.
“The players, too, will certainly want to deliver the first win in their history at the ground for the supporters who suffered the heartache last season, but it is as much about taking points off another promotion rival.
“Chris Hughton’s side have the best defence in the Championship but the manager believes their opposition are stronger after their summer recruitment.
“His own team is arguably weaker this weekend, hampered by the absence of Dale Stephens (suspended) and Beram Kayal (injured), who were the mainstays of his midfield last season. A tight game is no doubt in prospect.”
Sheffield Wednesday are unbeaten in their last nine league matches (including play-offs) against the Seagulls, winning four and drawing five.
Brighton have failed to score in six of their last seven league and play-off clashes with the Owls, but did find the net last time out in the second leg of their play-off semi-final in May.
Wednesday have claimed 10 points after being behind this season in the Championship, more than any other side, with nine of those coming at home.
Brighton have shipped just six goals in their opening 10 fixtures, fewer than any other Championship team.
The Seagulls have gone 380 minutes in the Championship without conceding.