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Rotherham boss Alan Stubbs is set to make several changes after their 2-2 Championship draw with Wolves.
Lee Frecklington (calf), Joe Mattock (knee) and Kirk Broadfoot (hamstring) are all struggling to be fit.
Aaron Wildig (ankle) will miss the tie for Morecambe after limping out of their League Two defeat by Grimsby.
The Shrimps will also be without summer signing Dean Winnard (knee), while captain Peter Murphy (knee) is likely to be out until October