Wayne Rooney is struggling with a back problem but Zlatan Ibrahimovic will start against Ukrainians Zorya Luhansk in the Europa League.
Mourinho is set to field a strong side but must weigh up whether to start his captain Rooney, who has been hampered by injury this week.
The United manager said he wanted to “protect” the striker, who was dropped to the bench against Leicester following heavy criticism of his performances.
Anthony Martial is fit again and is set to partner Ibrahimovic up front but Henrikh Mkhitaryan, Luke Shaw and Phil Jones will not be included.
United appear to have regained their momentum following a three-game losing run with victories over Northampton in the EFL Cup and Leicester.
They will aim to take three points in another competition on Thursday when they face minnows Zorya at home.
United’s Euro campaign got off to a disappointing start with defeat by Feyenoord two weeks ago, and midfielder Jesse Lingard feels victory at Old Trafford is essential.
He said: “That’s the most important thing. We need to carry on like we did against Leicester, and if we can do that I’m sure we’ll get the three points. It’s mainly about momentum. The Leicester game gave us a lot of confidence as a team.”