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Reading will have midfielder Garath McCleary available again following a three-match suspension for a red card.
Fellow midfielder Danny Williams will also be pushing for a return having missed the midweek defeat at Brentford with an ankle injury.
Chris Powell is in charge of Derby County for a second game following the suspension of manager Nigel Pearson.
Defenders Jason Shackell (calf) and Marcus Olsson, and midfielder Craig Bryson (both groin) could all return.
Reading striker Yann Kermorgant told BBC Radio Berkshire:
“Derby have got a massive squad. It didn’t work out for them at the start of the season, but I’m sure they will get better and we will have to be at our best to beat them.
“They won on Tuesday and will be more confident maybe, but it’s up to us and we’ve done well at home this season.
“We have to make sure that we carry that form on and believe in what we do.”
Derby caretaker boss Chris Powell on manager Nigel Pearson’s suspension:
“We have to get on with the job in hand. We have a responsibility to carry on with the jobs we do and make the sure the team is focused and the players are prepared and coached in the same manner.
“You have to be professional. People may roll their eyes when they hear that, but you are employed to do a job.
“Winning a football match [the 2-0 win away against Cardiff on Tuesday] always helps; it helps the players and the supporters.”
Former Reading captain and BBC Radio Berkshire presenter Ady Williams:
“Reading are unbeaten at home in all competitions so far this season, which should help them get back to winning ways.
“The return of Garath McCleary will also be a big plus for Jaap Stam. Defensively, it was the worse performance of the season in the 4-1 defeat by Brentford, but I think the manager will keep faith with the back four.
“As for Derby, surely it’s a matter of time before they start climbing the Championship table? While things are a little uncertain off the pitch, on it their 2-0 win at Cardiff in midweek will be a massive boost.
“The return to the Madejski Stadium of Nick Blackman and Matej Vydra should help generate a hostile atmosphere. Both possibly to make a point against their former club.”
Reading are winless in their last four league matches against Derby at the Madejski Stadium (D2 L2).
Indeed, the Rams have kept a clean sheet in each of their past three visits to Reading in league competition.
Reading have conceded five times in the opening 15 minutes of the second half – no Championship team has conceded more in this period.
After 13 games this season, Derby finally scored more than one goal in a game by beating Cardiff 2-0 in midweek.
The Royals are unbeaten at home in the Championship this season, winning three and drawing two.
Tom Ince’s strike against Cardiff was his first league goal since April. He hasn’t scored in back-to-back league games since December 2015.