This summer, Wales reached the Euro 2016 semi-finals, where they were beaten by Portugal as Ramsey watched from the stands because of a ban for collecting two yellow cards during the tournament.
Speaking after announcing his squad to face Moldova, Coleman said: “If you look at Rambo’s physical stats, they’re higher than anybody on the pitch in terms of his high-intensity sprints and the kilometres he covers.
“But he’s still a human being, and it’s not like we were knocked out in the group stage, it was a long tournament for Aaron, after a long, hard season.
“So I don’t know why he was treated differently.
“For me as a manager, when I’m missing one of my best players, I think anybody would understand my disappointment.”
Coleman says he does not expect Arsenal to change their approach and will not use the Ramsey situation against the Gunners.
“I think Arsenal have a certain way of doing things,” he said.
“A lot has been said about their injury list, they’re doing the same things now as they’ve always done – they’re not going to change now.
“That’s up to them, Aaron’s Arsenal’s player. I’ve got to say that I look at it and I’m disappointed because we’ve lost a great player.
“I’m not going to say, ‘in hindsight’, because I’m doing a job myself and I make decisions and sometimes look back and think I shouldn’t have made that decision.
“So I won’t use that against Arsenal. It’s disappointing that we haven’t got him.”