Mauricio Pochettino’s side will hope to put some of the disappointments of last season behind them by starting this campaign with a win.
But a trip to Merseyside to face Ronald Koeman’s Toffees will be no simple task.
Luckily, their defence is looking solid with Jan Vertonghen returning for the clash, according to Pochettino.
So who else are Spurs likely to field for the match?
Click through the gallery above to see our predicted Tottenham line-up v Everton.