Mauricio Pochettino is expected to ring the changes once more as Tottenham take on Borussia Dortmund for the second time in seven days.
The Spurs boss made seven changes last week as a youthful line-up were routed 3-0 by a ruthless Dortmund display, but the Argentine coach could once again change virtually his entire team as he prioritises SundayÂ’s Premier League clash against Bournemouth.
Harry Kane, Mousa Dembele, Dele Alli, Erik Lamela, Toby Aderweireld and Christian Eriksen could all be rested, while Kyle Walker and Danny Rose could be omitted as the manager once again rotates his full-backs.
Nacer Chadli could be called upon to spearhead the Tottenham attack with 18-year-old Josh Onomah and Son Hueng-min also pushing for recalls.
Ryan Mason, Ben Davies, Kieran Trippier and Tom Carroll all started the first leg and Pochettino is likely to put his trust in his squad players again.
Jan Vertonghen has been making progress in his injury comeback, but is not likely to start after only returning to light training on Sunday.