West Ham boss Slaven Bilic is without defender Arthur Masuaku for Southampton but can welcome back centre-half Winston Reid.
Masuaku, whose defending has been erratic to say the least, damaged ankle ligaments in midweek and is expected to be out for at least six weeks but Reid returns after a couple of weeks on the sidelines.
Bilic also had positive injury news on Aaron Cresswell as well as injury-hit striker Andy Carroll.
“It was in the papers on the day we played Accrington that Carroll had had a setback, but it’s not true,” the boss said. “We are expecting him and Cresswell to join and train with the team after the international break.
“Injury-wise we look much better than at the beginning of the season. We have a good team and I expect us to be really good in every way on Sunday afternoon.”
Summer signing Andre Ayew and fellow forward Diafra Sakho are still out injured.
The visit of Saints is the first Premier League match at the London Stadium since trouble flared among fans during the 4-2 defeat by Watford.
The West Ham board are attempting to solve the problems by improving stewarding, relocating disgruntled fans and beefing up the segregation between rival supporters.
Defeat on Sunday could see West Ham slump to the foot of the table so Bilic has urged the fans to put the off-field issues to one side and back the team.
“I want the fans to be behind us, and they will be,” he added. “We need their support more than ever and they will play a big part in this game. We need them all the time, but especially now to help get out of this situation. I have no doubt they will be very positive.”