Newcastle captain Fabricio Coloccini and fellow defender Daryl Janmaat are expected to miss the rest of the season because of injury.
However, midfielder Yoan Gouffran is available again and Steven Taylor is close to regaining fitness.
Crystal Palace manager Alan Pardew says Wilfried Zaha is “50-50” to recover from a leg injury in time for Saturday’s game.
Marouane Chamakh, Brede Hangeland and Paddy McCarthy are long-term absentees.
MOTD COMMENTATOR’S NOTES
Jonathan Pearce: “Alan Pardew would hate to be the man to all-but send Newcastle United down.
“For all the bitter social media attacks on him in his last months in charge, he still has a big place in his heart for a club that wouldn’t be in its current perilous predicament if he had stayed.
“But if he picks up a point on his return, the Toon will be effectively doomed.
“A Geordie win, though, would give Rafa Benitez a great chance of keeping them up. Palace haven’t won there since 1998. Focus might be blurred with Wembley on the minds of some.
“It’s now or never for Newcastle. Aleksandar Mitrovic is key.”
WHAT THE MANAGERS SAY
Newcastle United manager Rafael Benitez: “We know we can beat anyone, especially at St James’ Park.
“If we show the same passion, character and intensity that we have in recent games, I think we will win matches.
“We need to believe because we’ve set the standard in the past few games and we need to keep it.”
Crystal Palace manager Alan Pardew on Newcastle: “Of course I want them to stay up. A lot of the players are close to me there. I’m desperate for them to stay up.
“Having said that, my job is to get three points for Crystal Palace. Rafa [Benitez] has got this team in a much better place to win this game and that worries me.”
Crystal Palace are on a good run in the Premier League – they have only lost once in five games – and now they are in the FA Cup final as well.
Newcastle’s form has picked up too and you could argue this game is their cup final, which is why I am backing them to win it.
Lawro’s full predictions v comedian Nathan Caton
- Think you can do better than Lawro? Predict the score for this match and the rest of this round’s Premier League fixtures in our Predictor game.
- Crystal Palace haven’t beaten Newcastle at St James’ Park since March 1998.
- The Magpies are unbeaten in six home meetings with Palace in all competitions (W4, D2).
- Newcastle have lost just one of their last seven league games at St James’ Park (W3, D3).
- They could go four league matches without defeat for the first time since Alan Pardew was in charge between October-November 2014.
- The Magpies’ last six goals have all been scored by different players (Colback, Cisse, Anita, Townsend, Sissoko and Lascelles).
- Newcastle striker Papiss Cisse has scored in all three of his Premier League matches against Crystal Palace.
- Crystal Palace have won just one of their last 18 league matches (D7, L10).
- Their last league victory away from home was on 19 December at Stoke, although they have won three away games in the FA Cup in 2016.
- They have won a joint-league low tally of eight points in the Premier League in 2016, alongside relegated Aston Villa.
- Palace have scored 18 goals from set pieces this season – only Tottenham (20) have scored more.
- Emmanuel Adebayor has scored six goals and assisted six more in his last nine Premier League games against Newcastle.
SAM (Sports Analytics Machine) is a super-computer created by Professor Ian McHale at the University of Salford that is used to predict the outcome of football matches.