The San Siro club had been one of the frontrunners in the race to land the dynamic Sporting Lisbon midfielder, who starred for Euro 2016 winners Portugal this summer.
However, reports in Italy have suggested that axed Inter boss Roberto Mancini had been concentrating on other targets, which had resulted in them falling behind the likes of Chelsea and PSG, despite already making one bid.
But now Frank de Boer is in charge, Inter are ready to go back for Mario, having had an offer worth around £30million rebuffed by Sporting last month.
The 23-year-old midfielder was high on the agenda when De Boer met with the club’s sporting director Piero Ausilio and, according to the Gazzetta dello Sport, the new manager has decided the squad needs a midfielder of Mario’s stature.
And now Inter are lining up an offer they hope will be enough to tempt Sporting to finally sell.
However, the Italian giants could face fierce competition as French moneybags PSG remain interested in the young midfielder, while Liverpool have also been linked with a late bid.