Luke Shaw and Anthony Martial look set to miss out when Manchester United face Northampton in an EFL Cup third-round tie on Wednesday.
Left-back Shaw sustained a slight groin tear in Sunday’s defeat to Watford, which forward Martial left during the first half following a nasty-looking clash of heads.
Henrikh Mkhitaryan is also a doubt for a match Phil Jones (knee) misses out on, while Red Devils manager Jose Mourinho will be tempted to make more changes on Wednesday, as he did in the Europa League at Feyenoord last week.
Michael Carrick, Ashley Young, Marcos Rojo and Daley Blind are all pushing for starts at Sixfields Stadium.
Manchester United squad: De Gea, Romero, Johnstone, Valencia, Darmian, Bailly, Blind, Fosu-Mensah, Rojo, Smalling, Tuanzebe, Carrick, Fellaini, Herrera, Mata, Depay, Pogba, Schneiderlin, Young, Mkhitaryan, Lingard, Rooney, Ibrahimovic, Martial, Rashford.