The Frenchman has trained with his new Spurs team-mates this week after making a £30m transfer deadline day move from Newcastle.
He is battling for a first-team place with Eric Dier and Victor Wanyama while Mousa Dembele serves out his six-match suspension hanging over from last season.
Spurs travel to Stoke on Saturday before hosting Monaco in the Champions League on Tuesday.
Boss Mauricio Pochettino said: “Sissoko is maybe in the squad [against Stoke].
“He arrived with us for the first time yesterday and he was in a good condition, but I will decide tomorrow.