Forest parted ways with manager Mark Warburton on New Year’s Eve and have since secured a 0-0 draw at promotion-chasing Leeds under the stewardship of caretaker boss Gary Brazil.
However, that draw extended the Reds winless run to five matches and they are now closer to the Championship relegation zone then they are the playoff positions.
Forest also have an underwhelming record in the FA Cup of late, as they have only made it beyond the third round of the competition in two of the last six years.
Forward Daryl Murphy remains an injury doubt having missed the game against Leeds with a knock, so Ben Brereton could continue in a loan-striker role.
Arsenal have been the dominant force in the FA Cup over recent seasons, winning the tournament in three of the last four years, including last season’s 2-1 triumph over Chelsea.
In total boss Arsene Wenger has guided the Gunners to seven successes in the FA Cup, while they have never been eliminated at the third round stage of the competition under the Frenchman’s stewardship.
The North Londoners have also won their last four meetings with Forest, including a 4-0 triumph in last season’s League Cup.
Wenger will have to watch the match from the stands, however, after he was handed a three-match touchline ban, while midfielder Granit Xhaka will miss the contest with a groin complaint and he joins Sead Kolasinac, Aaron Ramsey, Olivier Giroud and Nacho Monreal on the sidelines.