Manchester United will be without the suspended Juan Mata but Jesse Lingard is available after a European ban.
Wayne Rooney, Luke Shaw and Ashley Young are among the club’s long-term absentees.
West Ham have Enner Valencia, Victor Moses and Joey O’Brien available following injury lay-offs.
Winston Reid could also return, but fellow defenders James Tomkins and James Collins are injured and Sam Byram is cup-tied.
MOTD COMMENTATOR’S NOTES
Steve Wilson: “It wasn’t just losing, it was the manner of their defeat at Liverpool which would have stung the travelling Manchester United fans, which included Gary Pallister, Andy Cole and Denis Irwin. Who knows what Sir Alex made of it from the posh seats?
“United could yet progress past Liverpool, they could yet finish in the top four, but the feeling that neither is likely makes this cup tie against West Ham all the more important.
“The Hammers couldn’t be happier. They have won their last four games, and made ridiculous the notion that staying in the Premier League was their season-goal before moving to Stratford with a thrilling combination of adventure and skill.”
West Ham manager Slaven Bilic: “They are like a wounded lion, they have a massive game against us. It’s going to be very difficult but are we confident? Yes of course we are confident, but not because Manchester United didn’t play well (against Liverpool). We are confident because we are playing well.
“But it would be dangerous, suicidal, if we approach the game like ‘they are playing badly, we are playing well, and we are going to cruise it’. No way we will do that.”
This is going to be a tough one for Manchester United.
The Hammers do not let teams bully them away from home and they are great at coming from behind in games. They can take the tie back to Upton Park – and I fancy them to win it there.