Manchester United will assess defender Marcos Rojo, who was forced off against Arsenal on Sunday, although his injury is not considered serious.
Donald Love is out with a hamstring problem, meaning United could be without up to 17 players because of injury on Wednesday.
Jose Jurado again misses out for Watford with a calf injury.
Etienne Capoue is fit despite being substituted because of tiredness in Saturday’s draw with Bournemouth.
MOTD COMMENTATOR’S NOTES
Steve Wilson: “When one national newspaper singled out five Manchester United youngsters who could follow Cameron Borthwick-Jackson into Louis van Gaal’s first team only three months ago, Marcus Rashford didn’t even get a mention.
Watford head coach Quique Sanchez Flores: “We are positive, we have in our mind the opportunity to add these points against Manchester United but, of course, we are expecting a difficult match, very tough.
“United are on a good run, playing well, a young team, very quick with skill.
“But we are always in our line, our way, respecting the teams but always we are there to be competitive and add points in the matches.”
I think Watford will be a tough nut to crack defensively and they will also look to hit United on the break, so they will cause Louis van Gaal’s side some problems.