Manchester United pair Luke Shaw and Henrikh Mkhitaryan could return from illness and injury respectively.
Phil Jones remains absent with a knee problem, while Wayne Rooney is pushing for a starting spot after impressing off the bench on Thursday.
Stoke midfielder Joe Allen has not trained since last weekend due to a tight hamstring and is a doubt.
Forward Jon Walters could return after an ankle injury but goalkeeper Jack Butland remains sidelined.
MOTD COMMENTATOR’S NOTES
Steve Bower: “Jose Mourinho will be aiming for Manchester United to get close to replicating last weekend’s first-half display, while Mark Hughes will be hoping his former club are more in the mode of Thursday’s laboured Europa League victory.
“The opening 45 minutes against Leicester last weekend has set the standard for Mourinho’s United. The crowd responded too, the stadium was a throwback to you know who. The handbrake was well and truly released.
“They will be confident of accelerating against Stoke – a side that has conceded four times on three occasions this season. Defensive shape will have been top of their training list this week; Stoke simply have to stay in the game.”
WHAT THE MANAGERS SAY
Manchester United manager Jose Mourinho: “It is another poisoned gift because Stoke is not what the table says. The manager is very good, the players are good, the team is good, so when I look to the table, that’s not Stoke’s position.
“I play against a good Stoke and not the Stoke in that position in the table.”
Stoke City manager Mark Hughes: “We think it’s only a matter of time before it comes because we’re not playing badly. The last two games I’ve seen a confident team, a team that wants to address the situation and get the maximum points.
“It’s not as if our confidence has been affected, we’re fine in that regard, but clearly we want to get three points on the board as quickly as possible.
“It’s going to be difficult this weekend because clearly our record at Manchester United isn’t great. It’s a big ask but, if we’re going to get a first win on the board, why can’t it be at Old Trafford?”
The Potters should have held on to beat West Brom last week but that is the way they are at the moment, and I cannot see them holding out at Old Trafford for 90 minutes.
- Think you can do better than Lawro? Predict the score for this match and the rest of this round’s Premier League fixtures in our Predictor game.
- It is 40 years since Manchester United lost at home to Stoke – a 1-0 defeat in April 1976.
- Stoke have only won five of their 43 matches away to United.
- United have won 15 of the last 16 home league meetings in all competitions, drawing the other.
- United have responded to a run of three straight defeats in all competitions with three successive victories.
- Thursday’s 1-0 Europa League win ended a run of five games in all competitions without a clean sheet.
- They have won five of the last seven Premier League games that Wayne Rooney hasn’t started.
- Rooney has scored four goals and set up two in his last three home league appearances against Stoke.
- Stoke and Sunderland are the only teams yet to win a league game this season (D2, L4).
- Four of the last six Premier League teams to take just two points from their opening six games have been relegated.
- Stoke have now won just one of their last 13 Premier League games (D4, L8).
- The Potters – and Bournemouth – are the joint-lowest Premier League scorers this season with four goals.
- They have gone 16 Premier League games without a clean sheet.
SAM (Sports Analytics Machine) is a super-computer created by @ProfIanMcHale at the University of Salford that is used to predict the outcome of football matches.