Stoke midfielder Joe Allen has not trained since last weekend due to a tight hamstring and is a doubt.
Forward Jon Walters could return after an ankle injury but goalkeeper Jack Butland remains sidelined.
MOTD COMMENTATOR’S NOTES
Steve Bower: “Jose Mourinho will be aiming for Manchester United to get close to replicating last weekend’s first-half display, while Mark Hughes will be hoping his former club are more in the mode of Thursday’s laboured Europa League victory.
“The opening 45 minutes against Leicester last weekend has set the standard for Mourinho’s United. The crowd responded too, the stadium was a throwback to you know who. The handbrake was well and truly released.
“They will be confident of accelerating against Stoke – a side that has conceded four times on three occasions this season. Defensive shape will have been top of their training list this week; Stoke simply have to stay in the game.”
Manchester United manager Jose Mourinho: “It is another poisoned gift because Stoke is not what the table says. The manager is very good, the players are good, the team is good, so when I look to the table, that’s not Stoke’s position.
“I play against a good Stoke and not the Stoke in that position in the table.”
Stoke City manager Mark Hughes: “We think it’s only a matter of time before it comes because we’re not playing badly. The last two games I’ve seen a confident team, a team that wants to address the situation and get the maximum points.
“It’s not as if our confidence has been affected, we’re fine in that regard, but clearly we want to get three points on the board as quickly as possible.
“It’s going to be difficult this weekend because clearly our record at Manchester United isn’t great. It’s a big ask but, if we’re going to get a first win on the board, why can’t it be at Old Trafford?”
The Potters should have held on to beat West Brom last week but that is the way they are at the moment, and I cannot see them holding out at Old Trafford for 90 minutes.