Manchester City striker Sergio Aguero begins a three-game ban but Bacary Sagna should be in contention after recovering from a hamstring injury.
Leroy Sane and Ilkay Gundogan are now fit and may make their debuts, as could goalkeeper Claudio Bravo.
Captain Vincent Kompany is back in full training following a thigh problem, but the club are unlikely to rush the injury-plagued defender back to action.
MOTD COMMENTATOR’S NOTES
Guy Mowbray: “Too early in the season to tell us anything decisive, but never too early to be enjoyed – all over the world thanks to a multi-time zone friendly kick-off time.
“As all good derbies should be, it’s almost impossible to predict – and all we know for sure is that with 100% starts behind both teams, something’s got to give.
“For all the history between the coaches, I hope that the focus afterwards is on what we’ve seen on the field rather than Jose Mourinho versus Pep Guardiola off it.
“United could be at just about full strength, whilst City will miss Sergio Aguero – but maybe not significantly. As shown against West Ham, this team can score without a major contribution from their number 10.”
This is only the second time that both Manchester clubs have won their opening three league games. The other occasion was in 2011, when City went on to claim the title ahead of United on the final day.
Wayne Rooney has scored 11 goals in Manchester derbies – more than any other player in this fixture.
Zlatan Ibrahimovic has scored 41 times in 34 league games since the start of last season.
Jose Mourinho is the first manager to win his opening four games in charge of Manchester United (includes Community Shield).
Pep Guardiola is the first Manchester City manager to win his opening five matches in charge of the club.
Raheem Sterling has scored or assisted five goals in four games under Pep Guardiola – as many as he produced in his last 22 matches under Manuel Pellegrini.
Kevin de Bruyne has provided 15 assists in league and cup since debuting for City, five more than any other player at the club.
The suspended Sergio Aguero has scored seven goals in eight league games against United.
SAM (Sports Analytics Machine) is a super-computer created by @ProfIanMcHale at the University of Salford that is used to predict the outcome of football matches.