Arsenal are desperate for three points to keep leaders Leicester City within touching distance, but face a resurgent United at Old Trafford.
The Gunners beat Leicester in their last Premier League outing, only for the Foxes to pick up three points yesterday and stretch their lead to five points.
Arsenal, meanwhile, lost 2-0 at home to Barcelona in the Champions League in midweek, meaning their hopes for silverware are almost certainly down to the domestic front.
That competition arguably represents United’s best chance of qualifying for next season’s Champions League, but Louis van Gaal remains hopeful of his side hauling in neighbours Man City for the Premier League’s fourth place.
Victory over Arsenal would put United three points behind City, albeit having played a game more.