A combination of poor finishing and heroic Burnley defending ensured Manchester United had to settle for a point at Old Trafford.
The home side were on top for long spells but they lost some momentum midway through the second period when Ander Herrera was sent off for a second bookable offence.
Former Red Devils youngster Tom Heaton was outstanding in the visiting goal while Ben Mee stepped in to deny United when Heaton was in trouble.
Zlatan Ibrahimovic was wasteful in front of goal while substitute Wayne Rooney blazed over a decent chance in stoppage time.
Jose Mourinho’s side started brightly, with Ibrahimovic testing Heaton within 30 seconds of the kick-off. Juan Mata and the Swede again drew saves before 20 minutes had elapsed.
At the other end, Sam Vokes led a Burnley breakaway but he dragged a shot wide from 20 yards.
With half-time in sight, Burnley somehow survived a rapid onslaught. Ibrahimovic combined with Paul Pogba but Mee was in the right place to divert the former’s shot away from goal.
Seconds later and Jesse Lingard’s glancing header seemed destined for the top corner, only for Heaton to get fingertips to it.
Matteo Darmian went to ground in the penalty box on the stroke of half-time but referee Mark Clattenburg was unmoved by his claims for a spot-kick. Mourinho’s remonstrations saw him banished to the stand for the second half.
Scott Arfield had Burnley’s clearest chance of the afternoon on 55 minutes. Michael Keane nodded down but the midfielder was unable to keep his volley below the crossbar.
On the hour, Heaton produced a heroic one-handed stop to deny an acrobatic effort from Ibrahimovic at the back post.
Herrera, booked in the first half, was perhaps unfortunate to slip as he charged towards Dean Marney on 68 minutes, leaving Clattenburg with little option but to brandish another yellow and subsequent red card.
Marouane Fellaini, Memphis Depay and Rooney were thrown on to secure a winner, but Mee produced an outstanding headed clearance with Fellaini behind him and poised to convert a Pogba cross on 88 minutes.
From another Pogba delivery, Ibrahimovic fired the wrong side of the post from six yards with the goal at his mercy.
In stoppage time, Daley Blind’s low free-kick picked out Rooney unmarked inside the penalty box but he fired over the crossbar.