The will be the first meeting since the rival bosses took charge of the city rivals in the summer. Not only is it significant for this reason, it is important in terms of the title race.
The two clubs have both spent well over £100m each in the summer transfer window, so the match will also be a coming together of some of the world’s most expensive stars.
Last season, the two meetings produced just one goal in total. The Old Trafford clash was a stalemate, while in the reverse fixture Marcus Rashford scored on his first Manchester derby appearance to give his side a 1-0 win at the Etihad.
In total, United have won 70 competitive meetings, City winning 49 and the match ending in a draw on 51 occasions.
So, how will Saturday’s match end up?
Cast your vote below!