Manchester City midfielder Samir Nasri is doubtful with the muscle injury which saw him miss Tuesday’s match.
Raheem Sterling could be involved from the start after returning as a substitute against Newcastle.
Stoke will be without midfielder Xherdan Shaqiri after he suffered a hamstring injury against Tottenham.
Shay Given is expected to continue in goal, while Jon Walters and Glen Johnson are getting close to a return but won’t feature on Saturday.
MOTD COMMENTATOR’S NOTES
Alistair Mann: “Ahead of one of the most important matches in their history, Manchester City can’t afford to lose their league focus as the genuine possibility of finishing outside the top four still remains.
“With Real Madrid looming, only by securing 10 points from their final four games will they guarantee a return to Europe’s coveted competition for when the Pep Guardiola era commences.
“While Manchester United are on FA Cup duty, a victory would open up a five-point gap over their rivals and they could do with the breathing space.
“A run of one win in their last six league matches has seen Stoke’s encouraging campaign begin to fizzle out but a first ever Premier League double against Saturday’s opponents would certainly revive it.”