Manchester City will be without captain Vincent Kompany, who suffered a recurrence of a calf injury against Dynamo Kiev in midweek.
Fellow central defender Nicolas Otamendi, who picked up a dead leg in that game, should be fit.
United’s Ander Herrera is a doubt with a groin problem that forced him to miss the Europa League clash with Liverpool.
Ashley Young and Cameron Borthwick-Jackson have both returned to training after injury and could feature.
MOTD COMMENTATOR’S NOTES
Steve Wilson: “The 171st Manchester derby could more or less signal the end of the line for City’s title hopes, or for United’s attempts to qualify for the Champions League.
“With United so poor away from home, City must be favourites to make it three successive home league wins against their neighbours for the first time since 1955.
“United’s recent defeats at Sunderland, Midtjylland, West Brom and Liverpool have been punctuated by only one win – at Shrewsbury.
“Their 1-0 win at Anfield is their only away win in the Premier League in four months.
“But City are not in great shape either, and it could be that the smart money goes on a draw.”
WHAT THE MANAGERS SAY
Manchester United manager Louis van Gaal: “I hope City is the catalyst. We have to beat City and we have a chance to still qualify [for the Champions League].”
City will be lying in wait for Manchester United because Louis van Gaal’s side have to deal with their Europa League tie against Liverpool on Thursday night.
The likes of Yaya Toure, Sergio Aguero and David Silva are big-game players for City, and I would expect them to make the difference.
Lawro’s full predictions v BBC athletics commentator Steve Cram
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- Manchester City have won four of the last six league derbies, although neither of the last two.
- United have won just one of their last five league visits to the Etihad Stadium (D1, L3).
- City are looking for their 50th competitive win in the Manchester derby (W49, D51, L70).
- There were just two shots on target in this fixture back in October. The match ended 0-0.
- City have won just one of their last five Premier League games (D1, L3).
- They have scored four goals in three of their last six home matches, but just two in total in the other three.
- Manuel Pellegrini’s side have scored 39 league goals at home this season, 10 more than any other top-flight team has managed prior to the weekend.
- City’s tally of 51 points after 29 games is their lowest at this stage of a Premier League season for seven years.
- Forty two of City’s 51 points (82%) have come against sides currently in the bottom half.
- United have taken just one point from a possible nine in their last three away games, losing to both Sunderland and West Brom.
- They have won just one of their last eight away games (D3, L4).
- Only Wayne Rooney (18) has been directly involved in more goals than Anthony Martial (16) in all competitions for United this season.
- Marcus Rashford has been involved in three of Manchester United’s last four league goals, scoring twice and setting up another.