Sergio Aguero is set to return and Ilkay Gundogan could make his debut as Manchester City begin their Champions League campaign against Borussia Monchengladbach on Tuesday.
Striker Aguero is one game into a three-match domestic ban and missed Saturday’s win at Manchester United.
But he is fit to play despite missing Argentina’s recent World Cup qualifiers with a calf problem.
Summer signing Gundogan has yet to play for City because of a dislocated knee.
The former Dortmund midfielder, 25, suffered the injury last season and has been out since May.
However, City boss Pep Guardiola said: “Gundogan every day and every week is much, much better.”
The Spaniard also revealed that defender and club captain Vincent Kompany is nearing a return to first-team action.
The Belgian, 30, has not played this season because of a thigh problem that caused him to miss this summer’s European Championship in France.
“Vincent is in the same situation – he’s training hard,” added Guardiola. “All of the players who didn’t face United did hard training and he trained really good.
“They are almost there to help us play the next six games in the next 18 days.”
City beat rivals Manchester United 2-1 on Saturday to maintain their 100% start to the season under new boss Guardiola and stay top of the Premier League.
City reached the Champions League semi-finals last season – the same stage at which Guardiola’s Bayern Munich were eliminated.
The Spaniard, who won three successive league titles during his time in Germany, admits it will be tough to win Europe’s premier club competition in his debut campaign in Manchester.
“I have to be honest, I would have to be a really good coach to win the Champions League this season,” he added. “I will try but the history is the history.
“If they believed I failed in Munich because I didn’t win the Champions League I have to accept that but I never said it is how I would be judged.
“I just try to analyse things to improve because you can always do better. We did good things and not so good things.
“If we don’t achieve it, it is because others have been better than us.”
Borussia Monchengladbach reached the group stage after beating Swiss side Young Boys 9-2 on aggregate in the play-off round.
“I understand Manchester City might be trying to soften expectations but they have incredible strength,” said Monchengladbach boss Andre Schubert.
“Manchester City has a great chance to win one or two trophies.”
The home side will be without Germany midfielder Patrick Herrmann because of a groin injury.