Manchester City captain Vincent Kompany won’t be involved after suffering a groin injury during the defeat by Real Madrid on Wednesday.
David Silva, Pablo Zabaleta and Aleksandar Kolarov have also been ruled out because of injury.
Arsenal midfielder Alex Oxlade-Chamberlain will miss the rest of the season and Euro 2016 after suffering his second knee injury of the campaign.
Per Mertesacker is out for the next two matches with a hamstring problem.
MOTD COMMENTATOR’S NOTES
Guy Mowbray: “Whilst not the title decider it might have been, there’s still a lot riding on this.
“An Arsenal win would guarantee them at least third place – and a top-four finish for an incredible 20th year in a row.
“With Villa at home for the last game they should get there anyway, which makes this match more about City.
“Manuel Pellegrini’s men may need to win their final two games for him to bequeath Pep Guardiola a Champions League place, and it would be a shame for him to leave on a down note of not doing it.
“Although Wednesday’s tame display in Madrid was a downer that will take some recovering from.”
WHAT THE MANAGERS SAY
Manchester City manager Manuel Pellegrini: “It’s a special game because we finish here at home after three intensive years. We’ve always received support of the fans, so we’re really happy with them.
“For me, the second season was the worst – if we can finish in third in this third season it wouldn’t be extraordinary but still a good season.
“I will have emotions on Sunday but I prefer not to show them in an external way.”
Arsenal manager Arsene Wenger: “We have regrets because we had a chance to finish top of the league.
“Our target now is to secure our position in the Champions League next year.
“If possible, to get in second place and at least secure third and on Sunday we can achieve that. If we win the two games, we will be all right.”
A point would pretty much make sure of third place for the Gunners but I just do not fancy them away from home at the moment. I think too many of their players are on their holidays.
City will move above Arsenal on goal difference if they win, but are in danger of dropping out of the top four if they lose.
I am going for the former – it is Manuel Pellegrini’s final home game in charge of City and the players and fans will want to give him a decent send off.
- Think you can do better than Lawro? Predict the score for this match and the rest of this round’s Premier League fixtures in our Predictor game.
- Arsenal are unbeaten in their last four league meetings with Manchester City (W2, D2), winning the last two.
- The Gunners won 2-1 when the teams met in December – they haven’t completed the league double over City since 2007-08.
- Manchester City have already lost five league games at home this season – as many as they had lost in their previous four league campaigns combined.
- City have only won one of their 13 matches against the current top eight in the Premier League this season (D3, L9) – that victory came against Southampton.
- Manuel Pellegrini will take charge of his 57th and final home match in the Premier League as Manchester City manager. He has won 43 of his 56 matches (D5, L8) – a win percentage of 76.8%.
- Kelechi Iheanacho has averaged a goal every 86.9 minutes in the Premier League this season, the best rate of any player to score two or more goals.
- Arsenal are unbeaten in their last eight league matches, although they have drawn half of those.
- The Gunners have kept five clean sheets in their last seven league games. They could keep four consecutive clean sheets for the first time in two years.
- Olivier Giroud has failed to score in his last 15 Premier League appearances – his longest goal drought in the competition.
- Theo Walcott has scored three goals in his last two Premier League appearances against Manchester City.
SAM (Sports Analytics Machine) is a super-computer created by Professor Ian McHale at the University of Salford that is used to predict the outcome of football matches.