Guardiola, whose side host West Brom tonight, admitted losing German international Sane is a big blow.
He said: “We don’t have a left foot in that position, we don’t have guys to push up like full backs.
“Unfortunately we don’t have a left winger in that position, but we are going to adapt. There is not an ideal situation where everyone is fit and all the players are happy.
“The important thing is the team spirit and that people are still healthy and focused on what we have to do game by game.”
Manchester City have signed England Under-21 midfielder Jack Harrison from New York City FC and loaned him immediately to Middlesbrough