A groin problem means Adam Lallana is set to miss out for Liverpool, along with Georginio Wijnaldum after he was injured playing for Holland.
Defenders Nathaniel Clyne and Dejan Lovren are back in contention and fit-again Emre Can could make a first league start of the season.
Manchester United’s Henrikh Mkhitaryan and defender Luke Shaw are fit for the trip to Anfield following injuries.
Phil Jones is the only player sidelined in an otherwise fully fit squad.
MOTD COMMENTATOR’S NOTES
Guy Mowbray: “They met four times last season, but never really in the blood and thunder tradition of Liverpool v Manchester United.
“There wasn’t even anyone sent off! A rare thing in the recent history of a game many consider a bigger derby than any same city rivalry.
“Jose Mourinho v Liverpool has history too – and if he thinks the Anfield fans weren’t keen on him as Chelsea boss…
“Jurgen Klopp’s men are flying, whilst Mourinho’s feel they’re owed a ‘fat result‘ after dominating Stoke but drawing last time out.
“It could be a magic Monday.
“As for any red cards – in truth I hope ref Anthony Taylor has an efficiently quiet night after criticism of his appointment to the game.”
WHAT THE MANAGERS SAY
Liverpool manager Jurgen Klopp: “Apart from the table, it’s a very important game. I know about the history, I like the special stories. The whole world will watch this game, it’s a big honour to be part of it.
“At the end, it’s up to us to perform to our best. You cannot and should not ignore the special circumstance of a game like this. You have to be ready.
“They have big quality and we have to respect this, as we do. But this is Anfield. We have to show this. We have had a few nice atmospheres but I’m open for the best atmosphere. We need everybody in a Liverpool shirt in this game.”
Manchester United manager Jose Mourinho on concerns over disrespectful chanting at the game: “In football we have some football tragedies, if you can say that, which is a big match that you lost, the mistake that some player did, this kind of thing, and you can make fun of it in a positive way.
“But the human tragedy is something much more serious. It’s the last thing somebody should use in a football pitch because they were really big tragedies, not to forget but to respect.
“I will be really sad in such a big football match if that was a negative point.”
“It will be interesting to see how Manchester United cope with the Reds’ gegenpressing because I think Liverpool have been the best team in the league without the ball this season – they are as good when they don’t have possession as they are when they do.
“I think United will struggle to deal with that. Quite often with these big games I go for a draw but on this occasion I fancy Liverpool.”
- Think you can do better than Lawro? Predict the score for this match and the rest of this round’s Premier League fixtures in our Predictor game.
- A defeat for Liverpool will be the first time they have lost three straight home league games to Manchester United since January 2005.
- United have won their last four league games against Liverpool and seven of the last nine.
- That run of four defeats for Liverpool is their worst since losing five consecutive matches to United in March 2008.
- Liverpool have lost 67 league matches against Manchester United – more than against any other opponent.
- There hasn’t been a draw between the two sides domestically since a 1-1 league stalemate at Anfield in October 2011.
- Steven Gerrard, with eight goals, is the top scorer in this fixture in the Premier League era. Wayne Rooney and Robbie Fowler both have six.
- Liverpool are going for a fifth league win on the trot which would be their best run since March 2015.
- Since Jurgen Klopp was appointed as Liverpool manager in October 2015 they have scored a league high 73 goals and have the highest average possession figure of 58.8%.
- The Reds have failed to keep a clean sheet in their last nine league games.
- Klopp has lost just one of his five meetings with Jose Mourinho, winning three and drawing one.
- James Milner has been involved in 21 Premier League goals since the start of last season – nine goals and 12 assists – more than any other Liverpool player.
- Jose Mourinho’s men have won only once in their last four league games, conceding seven goals.
- Wayne Rooney currently has 87 Premier League away goals, the joint-most in the competition alongside Alan Shearer.
- Manchester United had three points more at this stage last season under Louis Van Gaal (16).
- Marcus Rashford has scored 12 goals since his debut for Manchester United on 25 February 2016, four more than any other United player.
SAM (Sports Analytics Machine) is a super-computer created by @ProfIanMcHale at the University of Salford that is used to predict the outcome of football matches.