Liverpool have lost their last four games to United and have never lost five times in a row.
But Klopp believes they are in much better shape to face their rivals than their 1-0 defeat by them in January when key men like Daniel Sturridge, Divock Origi and Philippe Coutinho were out injured.
He added: “This will be a completely different situation, that’s for sure. It’s the best moment for us to play these important games.”
Likely line up:
LIVERPOOL (4-2-3-1): Mignolet; Clyne, Sakho, Lovren, Flanagan; Can, Henderson; Firmino, Coutinho, Lallana; Sturridge.