Having missed an earlier penalty, Kane smashed the stoppage-time spot kick into the bottom corner and Anfield went from a sea of joy to an angry pit.
It was a fascinating match decided by two moments of magic from Salah, two controversial decisions, a missed penalty and a spot kick scored.
Oh, and a wonder strike from Victor Wanyama that will be criminally overlooked after all the drama of how the game ended.
Amid the madness, it is also an example of why both are miles behind Manchester City as, while it was exciting, it was also error-strewn.
The match started with a mistake as Liverpool took a third-minute lead after Eric Dier slotted Salah in by mistake and the Egyptian ace calmly sent Hugo Lloris the wrong way to find the bottom corner.