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Leeds are likely to start Luke Ayling at right-back after he joined from Bristol City on Thursday.
Ayling will replace Gaetano Berardi, who suffered a hamstring injury in Leeds’ 3-0 defeat by QPR in their first game under new head coach Garry Monk.
Che Adams could make his Birmingham City debut after he joined from Sheffield United for a £1.5m fee.
Tomasz Kuszczak, Clayton Donaldson and Diego Fabbrini are likely to play after missing the EFL Cup loss to Oxford.
BBC Radio Leeds commentator Adam Pope:
“United head coach Garry Monk says he will have no hesitation giving a debut to right-back Luke Ayling after he signed on a three-year deal from Bristol City on Thursday.
“Defender Gaetano Berardi remains out with a hamstring injury whilst goalkeeper Marco Silvestri is sidelined with a knee problem.
“United could give home senior debuts to as many as 10 players tomorrow, including Pablo Hernandez. The Spaniard, on loan from Al-Arabi, is the marquee signing of the summer and was the man of the match in the midweek EFL Cup victory at Fleetwood Town.”
Leeds have lost only one of their last six league meetings with Birmingham, winning three (D2) including the most recent one 2-1 away at Birmingham in April 2016.
The Blues have lost only one of their last six away trips to Elland Road in all competitions (W3 D2), though it was a 4-0 drubbing in October 2013.
Since a December 1987 meeting, Leeds’ 10 home league meetings with Birmingham have seen a different manager in the home dugout (Billy Bremner, Howard Wilkinson, Terry Venables, Peter Reid, John Carver, Simon Grayson, Neil Warnock, Brian McDermott, Neil Redfearn and Uwe Rosler).
Birmingham are winless in their last seven league games (D5 L2), keeping a clean sheet just once in that time.
Leeds were the only team in the Football League who failed to register a shot on target in their opening game of the 2016-17 campaign.