He made six changes to his side from the team beaten 1-0 at Birmingham last time out.
It meant a return to the side for Eldin Jakupovic, whose heroics at the Emirates last month earned Hull a second crack at the Gunners.
There is plenty of recent Cup history between the sides – they met in the third round last season and in the 2014 final when Arsenal edge to a 3-2 win in extra-time.
For Arsenal, it was seven changes from the team that drew 2-2 against Tottenham on Saturday.
Three of them came in attack, with Olivier Giroud flanked by Theo Walcott and Joel Campbell.
And it was Campbell who had the first sight of goal – the Costa Rican curling an effort wide of Jakupovic’s far post from the corner of the penalty area.
An injury to Petr Cech meant Wenger had little choice but to stick with David Ospina in goal.
The Colombia was in inspired form against Spurs on Saturday and Arsenal were grateful to him again as Hull threatened.