West Ham’s memorable win over Tottenham came at a cost with James Collins the latest player to be injured.
The Hammers could now be without up to seven senior defenders when they head to Everton on Saturday.
Collins is the latest casualty after suffering a hamstring injury, while Angelo Ogbonna had his ankle heavily strapped after limping through the second half.
Already missing Winston Reid, James Tomkins, Joey O’Brien and Carl Jenkinson due to injury and Sam Byram through suspension, West Ham finished the 1-0 Spurs victory with a makeshift back three of Ogbonna, youngster Reece Oxford and midfielder Cheikhou Kouyate.
Reid is the closest to a return following a hamstring problem although he is short of match fitness, while Wales international Collins now faces a spell on the sidelines.
“It’s his hamstring and it’s not a couple of days (out),” said Bilic. “We will wait until it settles down and assess it. The first information is that we should be happy if he only misses three games.
“After three games there is an international break, Easter and all that. But it’s a big blow for us, the whole season he has been magnificent.”