Prime Minister David Cameron announced his resignation after Leave secured a dramatic victory 52-48 victory last night.
And Chadwick reckons the Prem is set for an uncertain future too.
He added: “We are moving into uncharted territory here, this could have a big impact on the Premier League.
“If the pound continues to fall then foreign talent will become more expensive, so that could have a huge knock-on effect in the summer transfer window. Plus all the players coming to England to play, their wages are now worth a lot less than previously.
“In theory the Bosman ruling no longer applies to the Premier League, but there will still be some freedom of movement through things like Kolpak.
“We may see more players from the Commonwealth and less from Europe.”