Chelsea and Liverpool were both in action – and cruised into the next round.
Liverpool saw off Championship new boys Burton 5-0, while Chelsea edged past Bristol Rovers 3-2.
Here are all the other results from a busy night across the country.
Crystal Palace 2-0 Blackpool
Blackburn 4-3 Crewe
Burton 0-5 Liverpool
Chelsea 3-2 Bristol Rovers
Derby 1-1 Carlisle
(Derby win 14-13 on penalties)