Meanwhile for United, Antonio Valencia makes his own long-awaited return from injury.
The Ecuadorian has been out since October.
Andreas Pereira, Adnan Januzaj and Paddy McNair also start at Tranmere Rovers’ ground.
And Joe Riley and James Weir, both of whom were on the bench at Anfield last night, are in United’s line-up.
Liverpool: Ward, Randall, Smith, Skrtel, Caulker, Chirivella, Ibe, Brannagan, Sinclair, Kent, Ojo
Subs: Whelan, George, Madger Gomes, Maguire, O’Hanlon
Manchester United: Pereira, Valencia, Williams, McNair, Riley, El Fitouri, McTominay, Love, A. Pereira, Januzaj, Weir
Subs: Henderson, Fosu-Mensah, Poole, Rothwell, Redmond