David Luiz will make his first start for Chelsea since rejoining the club in a £34m switch from Paris Saint-Germain.
He replaces captain John Terry, who suffered an ankle ligament injury against Swansea last weekend.
Liverpool defender Dejan Lovren is expected to return against Chelsea after missing Saturday’s 4-1 win over Leicester because of a bruised eye.
There could be a recall for Philippe Coutinho, who was rested for that game after a long flight from Brazil.
MOTD COMMENTATOR’S NOTES
Simon Brotherton: “Liverpool’s tricky early run of fixtures continues, with unbeaten Chelsea certain to be fired up for this one after dropping points for the first time this season in last Sunday’s 2-2 with Swansea.
“Liverpool have already played last season’s top three, putting four goals past both Arsenal and Leicester and drawing at Tottenham.
“Unlike certain other encounters between these sides in recent times, there’s no league title or place in the Champions League final at stake, but the game will be no less intense for that.
“Liverpool were 3-1 winners in the corresponding fixture last season, which was also their first league win under Jurgen Klopp. I’m expecting a close, high-octane encounter to start the weekend.”